If the fitness, diet & nutrition industries were to diagnose Steve Jobs' weight problems, they'd likely say he wasn't eating enough, or was exercising too much.
I have no idea what Steve's hormone imbalance is, but I'd surmise it has something to do with insulin.
From the Telegraph article...
'The job of determining how fuels will be used - whether we will store them as fat or burn them for energy - is carried out by the hormone insulin with LPL,' says Taubes. 'Because insulin determines fat accumulation, it's quite possible that we get fat not because we eat too much or exercise too little, but because we secrete too much insulin.
Regardless of the underlying reason, here's hoping Steve recovers.